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Polyarteritis Nodosa
(PAN) |
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Polyarteritis nodosa (PAN) is a systemic
disease that affects small- and medium-sized arteries.
Polyarteritis nodosa is a systemic disease characterized by
inflammatory necrosis of the walls of small- and medium-sized
arteries.
Although the disease is systemic,it is patchy and focal, only parts of
some arteries being
involved.
The clinical effects of the disease are the result
of vessel occlusion leading to small areas of infarction,
and the tissues most seriously affected are the kidneys, heart,
alimentary tract, liver, central nervous system, peripheral nerves, skeletal
muscle, and skin.
The cause of the disease is unknown, but it is likely to be
immune-complex-mediated. There is an association with chronic hepatitis B virus
antigenaemia.
The artery wall shows infiltration by mixed inflammatory
cells, in which neutrophils and eosinophils are most numerous.
Fibrinoid necrosis of a segment of the artery wall is very common.
The inflammatory destruction leads to disruption of the
normal architecture of the vessel wall, with necrosis of muscle
cells and destruction of the elastic lamina; healing is followed
by fibrous replacement of these specialized structures.
During
the acute inflammatory phase, the extensive damage to the intima
predisposes to thrombosis, which is often followed by vessel
occlusion and infarction of the target tissue. |
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We give here simplified and accurate information about the disease
Info@somalidoc.com |
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