Acute liver failure results in jaundice, coma, and bleeding tendency 

Acute liver failure is seen in three main clinical situations:

• Following severe hepatocyte damage.

• Following severe systemic shock.

• As acute decline in chronic liver disease.

Acute liver failure, which develops when there has been damage to the majority of hepatocytes such that liver function is critically impaired, it is seen in three main clinical situations:

• Following severe hepatocyte damage, e.g. as a consequence of extensive liver cell necrosis or metabolic damage.

• Following severe systemic shock as part of multi-organ failure along with ARDS and acute renal failure.

• As an acute decline in otherwise stable chronic liver disease, usually caused by chronic hepatitis.

Development of acute hepatic failure is a severe life-threatening disease, from which 80% of patients die.