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Multiple Sclerosis |
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Multiple sclerosis is an immune-mediated
disease of uncertain cause
Multiple sclerosis (MS) is a disease in which there are relapsing episodes of
immunologically mediated demyelination within the CNS.
Loss of myelin leads to
failure of axonal function and neurological dysfunction.
The lesions of MS are confined to the brain and spinal cord. Areas of
demyelination are termed plaques, best seen at the angles of the lateral
ventricles, in the cerebellar peduncles, and in the brain stem, although they
can occur at any site in the CNS.
Histologically, there is myelin loss associated with lymphocytic cuffing of
small vessels. Macrophages enter the lesion and phagocytose damaged myelin,
accumulating lipid and forming foam cells. Astrocytes around plaque margins
become enlarged.
Areas of old myelin loss appear as sharply demarcated patches of firm,
gelatinous, greyish pink discoloration. |
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We give here simplified and accurate information about the disease
Info@somalidoc.com |

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