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Osteoporosis |
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Osteoporosis is characterized by reduced bone
mass and is the most common metabolic bone disease
Osteoporosis localized to one or both lower limbs is a common finding in people
with paralysis due to neurological disease, in which cases it is considered to
be a form of disuse atrophy. Reduction in general mobility and activity may be a
factor in osteoporosis in the elderly.
Osteoporosis is seen as a common complication of prolonged corticosteroid
therapy. It is particularly important when the corticosteroids are being
administered for diseases such as rheumatoid arthritis, in which there is also
an element of disuse atrophy due to reduction in mobility. Osteoporosis can also
be seen in some other endocrine disorders such as thyrotoxicosis and
panhypopituitarism, and associations have been reported with liver disease and
diabetes.
Osteoporosis is characterized by generalized reduction in the mass of bone, the
bone being composed of abnormally thin trabeculae. It is widespread in the
elderly and is an important cause of morbidity and even mortality, the weakened
bone being particularly predisposed to fracture with minimal trauma.
In established osteoporosis, thinning of the cortical bone is combined with
thinning and reduction in number of bone trabeculae. The consequences of
osteoporosis are related to the general weakening of both cortical and
trabecular bone.
There are several different predisposing factors for the development of
osteoporosis.
It is most commonly encountered in post-menopausal women, when it is termed
senile osteoporosis. It is believed that a major reduction in bone mass occurs
in the 10 years after the onset of menopause, implying a hormonal influence for
oestrogen in maintaining bone mass.
Osteoporosis localized to one or both lower limbs is a common finding in people
with paralysis due to neurological disease, in which cases it is considered to
be a form of disuse atrophy. Reduction in general mobility and activity may be a
factor in osteoporosis in the elderly.
Osteoporosis is seen as a common complication of prolonged corticosteroid
therapy. It is particularly important when the corticosteroids are being
administered for diseases such as rheumatoid arthritis, in which there is also
an element of disuse atrophy due to reduction in mobility. Osteoporosis can also
be seen in some other endocrine disorders such as thyrotoxicosis and
panhypopituitarism, and associations have been reported with liver disease and
diabetes. |
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We give here simplified and accurate information about the disease
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