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Silicosis |
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Silicosis is caused by inhalation of
quartz-containing dust.
Silicosis is caused by inhalation of silicon dioxide (quartz).
Short heavy doses produce acute silicosis with pulmonary oedema and alveolar
exudation.
Prolonged exposure leads to formation of multiple fibrous nodules composed of
collagen
in the lungs.
These expand and cause extensive destruction of lung tissue.
PMF may also develop. Histologically, silica particles can be seen in nodules,
using polarized light .
The pathogenesis of silicosis is thought to be a toxic effect on macrophages,
which
stimulates cytokine generation, precipitating fibrogenesis.
In silicosis, nodules of collagen contain silica particles. In this case, as is
common
when coal-mining exposure has occurred, there is additional carbon pigmentation,
resulting
in black peripheral staining. |
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